|
KMID : 1149219990070010143
|
|
Korean Journal of Oriental Medical Prescription
1999 Volume.7 No. 1 p.143 ~ p.151
|
|
|
Effect of Epimedium Koreanum Nakai on GO-Induced Neurotoxicity in Cultured Mouse Spinal Dorsal Root Ganglion Neurons
|
|
Park Seung-Taeck
Lee Ho-Sub
Yun Young-Gab
Park Byung-Rim
|
|
|
Abstract
|
|
|
|
To evaluate the neurotoxic effect of oxygen radicals in cultured mouse spinal dorsal root ganglion(DRG) neurons, cytotoxicity was determined by MTT assay after cultured DRG neurons were grown in the media containing various concentrations of glucose oxidase(GO). In addition, neuroprotective effect of herb extract, Epimedium Koreanum Nakai was examined by MTT assay in cultured DRG neurons. Cell viability of cultured DRG neurons was remarkably decreased by GO in dose- and time-dependent manner, and Epimedium Koreanum Nakai protected remarkably GO-induced neurotoxicity in these cultures. From the above results, it is suggested that oxygen radicals is toxic in cultured mouse DRG neurons, and herb extracts such as Epimedium Koreanum Nakai are effective in prevention of the neurotoxicity induced by oxygen radicals in cultured mouse DRG neurons.
|
|
|
KEYWORD
|
|
|
Glucoseoxidase, Neurotoxicity, Culturedspinaldorsalrootganglionneuron
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|